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Shanghai GenePharma
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Microsynth ag
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Bioneer Corporation
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Sirna Therapeutics
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Obio Technology Corp Ltd
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Image Search Results
Journal: Experimental and Therapeutic Medicine
Article Title: MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1
doi: 10.3892/etm.2019.8165
Figure Lengend Snippet: Treatment with the miR-448 inhibitor suppressed neuroinflammation in rats with chronic constriction injury. The protein levels of (A) IL-1β, (B) IL-6 and (C) TNF-α in the spinal cords of rats treated with miR-448 inhibitor or scrambled control were measured using ELISA 7 days post-surgery. *P<0.05 vs. the sham group; # P<0.05 vs. the CCI + scrambled group. miR, microRNA; KD, knockdown; IL, interleukin; TNF-α, tumor necrosis factor-α; LV, lentivirus.
Article Snippet:
Techniques: Control, Enzyme-linked Immunosorbent Assay, Knockdown
Journal: Experimental and Therapeutic Medicine
Article Title: MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1
doi: 10.3892/etm.2019.8165
Figure Lengend Snippet: SIRT1 abrogated the effect of miR-448 on neuropathic pain development. miR-448 inhibitor lentivirus, or miR-448 inhibitor and shSIRT1 lentivirus, were co-infected into CCI rats. (A) SIRT1 mRNA expression in CCI rats. (B) Mechanical allodynia as assessed by the PWT. (C) Thermal hyperalgesia as assessed by the PWL. The protein levels of (D) IL-1β, (E) IL-6 and (F) TNF-α in the L4-L6 spinal cords of rats were measured by ELISA on postoperative day 7. *P<0.05 vs. the CCI + scrambled group; # P<0.05 vs. the CCI + LV-miR-KD group. SIRT1, sirtuin 1; miR, microRNA, sh, short hairpin; CCI, chronic constriction injury; PWT, paw withdrawal threshold; PWL, paw withdrawal latency; IL, interleukin; TNF-α, tumor necrosis factor-α; LV, lentivirus; KD, knockdown.
Article Snippet:
Techniques: Infection, Expressing, Enzyme-linked Immunosorbent Assay, Knockdown